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1–3 However, it is not widely appreciated that some diseases are also associated with subnormal test results, defined as values below the lower limit of normal on local laboratory reports (Table 1)

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Dietary copper supplementation can increase the expression of hypoxia-inducible factor-1α (HIF-1α) in the small intestine, thereby enhancing intestinal barrier stability through the upregulation of P-glycoprotein and tight junction proteins (86)